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Health Literacy During Aging.
Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3.
Transcription factor mutations as a cause of familial myeloid neoplasms.
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Mirmira, Raghu
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Mirmira, Raghu
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Concept
Homeodomain Proteins
Academic Article
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ß cells.
Academic Article
Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.
Academic Article
Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.
Academic Article
The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.
Academic Article
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.
Academic Article
Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.
Academic Article
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.
Academic Article
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
Academic Article
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
Academic Article
Expression and function of Set7/9 in pancreatic islets.
Academic Article
The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter.
Academic Article
The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.
Academic Article
Transcriptional activity of the islet ß cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
Academic Article
Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.
Academic Article
Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins.
Academic Article
Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.
Academic Article
Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.
Academic Article
Maintenance of Pdx1 mRNA translation in islet ß-cells during the unfolded protein response.
Academic Article
Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
Academic Article
Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.
Academic Article
Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.
Academic Article
Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation.
Academic Article
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.
Academic Article
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
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Homeodomain Proteins